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4391887 
Journal Article 
Label-free electrochemical immunosensor based on flower-like Ag/MoS2/rGO nanocomposites for ultrasensitive detection of carcinoembryonic antigen 
Wang, Y; Wang, Y; Wu, Dan; Ma, H; Zhang, Y; Fan, D; Pang, X; Du, Bin; Wei, Qin 
2018 
1 
Sensors and Actuators B: Chemical
ISSN: 0925-4005
EISSN: 1873-3077 
255 
125-132 
WOS:000414151800015 
In this work, a label-free electrochemical immunosensor was developed for the quantitative detection of carcinoembryonic antigen (CEA). Flower-like Ag/MoS2/rGO nanocomposites were employed as the signal amplification platform of the designed immunosensor for the first time. Due to the synergistic effect between molybdenum disulfide (MoS2), reduced graphene oxide (rGO) and Ag nanoparticles (NPs), Ag/MoS2/rGO nanocomposites could provide a high sensitivity for the label-free electrochemical immunosensor. The detection mechanism was based on the monitoring of the electrocatalytic current response change towards the reduction of hydrogen peroxide (H2O2) when immunoreaction occurred on the surface of the electrode modified with Ag/MoS2/rGO nanocomposites. Using amperometric i-t curve to record the electrocatalytic process, the proposed immunosensor achieved an ultrasensitive and specific detection of CEA with a low detection limit of 1.6 fg/mL. Under optimal conditions, the fabricated immunosensor exhibited acceptable reproducibility, selectivity and excellent stability. This designed immunosensor could provide an effective method in the clinical diagnosis of other tumor markers. (C) 2017 Published by Elsevier B.V. 
Molybdenum disulfide; Reduced graphene oxide; Ag nanoparticles; Electrocatalytic activity; Immunosensor; Carcinoembryonic antigen 
IRIS
• Molybdenum
     Litsearch 2018
          WOS