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HERO ID
4469
Reference Type
Journal Article
Title
Single-breath diffusing capacity and lung volumes in small laboratory mammals
Author(s)
Takezawa, J; Miller, FJ; O'Neil, JJ
Year
1980
Is Peer Reviewed?
Yes
Journal
Journal of Applied Physiology (1985)
ISSN:
8750-7587
EISSN:
1522-1601
Volume
48
Issue
6
Page Numbers
1052-1059
Language
English
PMID
7380702
DOI
10.1152/jappl.1980.48.6.1052
Abstract
We measured the single-breath diffusing capacity for carbon monoxide (DLCO), total lung capacity (TLC), functional residual capacity (FRC), and residual volume (RV) in anesthetized male hamsters, rats, guinea pigs, and rabbits whose weights varied from 40 to 3,500 g. TLC (defined as an airway pressure of 25 cmH2O) was calculated by neon dilution. The DLCO was estimated by a modification of the single-breath method. There was a high correlation between body weight and our measurement of both the diffusing capacity and the lung volumes. No significant difference in DLCO was observed in rats when measured in different body positions, at airway pressures of 10 or 20 cmH2O, from FRC or RV, in male or female rats, or following hyperventilation.
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ISA-PM (2019)
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Chapter 4
1st Draft
Chapter 4
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Chapter 4
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