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HERO ID
4641542
Reference Type
Journal Article
Title
Low resting metabolic rate is associated with greater lifespan because of a confounding effect of body fatness
Author(s)
Duarte, LC; Speakman, JR
Year
2014
Is Peer Reviewed?
Yes
Journal
Age
ISSN:
0161-9152
EISSN:
1574-4647
Volume
36
Issue
6
Page Numbers
9731
Language
English
PMID
25502004
DOI
10.1007/s11357-014-9731-3
Web of Science Id
WOS:000346770900013
Abstract
A negative association between resting metabolic rate (RMR) and lifespan is the cornerstone of the rate of living and free-radical damage theories of aging. Empirical studies supporting a negative association of RMR to lifespan may arise from the correlation between RMR and both daily energy expenditure (DEE) and thermoregulatory activity energy expenditure (TAEE). We screened 540 female mice for higher and lower DEE and measured RMR in the resulting 324 (60 %). We then selected 92 mice in which there was no link between residual from the regression of RMR against body mass (BM) and residual of DEE against BM to separate the effects of these traits. Lifespan was not significantly related to body mass, DEE and TAEE, but significantly negatively related to RMR. Fat-free mass (FFM) and fat mass (FM) were both significantly positively related to RMR. After removing the effect of FFM on RMR, the association between RMR and lifespan remained significantly negative; however, after statistically removing the effect of FM on RMR, the significant association between RMR and lifespan disappeared. We conclude that the negative association between RMR and lifespan is primarily due to the effect of FM, with FM positively related to both RMR and mortality and hence RMR negatively to lifespan. In 40 additional screened mice, greater FM was also associated with greater oxidative damage to DNA.
Tags
IRIS
•
tert-Amyl ethyl ether (TAEE)
Initial Litsearch 6/2018
Pubmed
WOS
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