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HERO ID
4728431
Reference Type
Journal Article
Title
Determination of total phthalate in cosmetics using a simple three-phase sample preparation method
Author(s)
Liu, L; Wang, Z; Zhao, S; Duan, J; Tao, H; Wang, W; Liu, S
Year
2018
Is Peer Reviewed?
Yes
Journal
Analytical and Bioanalytical Chemistry
ISSN:
1618-2642
EISSN:
1618-2650
Publisher
Springer Verlag
Location
Heidelberg
Volume
410
Issue
4
Page Numbers
1323-1331
Language
English
PMID
29222654
DOI
10.1007/s00216-017-0774-z
Web of Science Id
WOS:000423033100014
URL
https://search.proquest.com/docview/2045831470?accountid=171501
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Abstract
A simple sample preparation method requiring minimal organic solvents is proposed for the determination of the total phthalate content in cosmetics by high-performance liquid chromatography-tandem mass spectrometry. The hydrolysis of phthalates and purification of interfering substances were performed in a three-phase system that included an upper n-hexane phase, a middle ethanol phase, and a lower aqueous alkali solution. This three-phase system utilized an incremental purification strategy. The apolar ingredients were extracted with n-hexane, the polar pigments accumulated in the ethanol phase, and the hydrolysis product, phthalic acid, remained in the hydrolysate. Under the optimized conditions, the correlation coefficients (r) for the calibration curves were 0.998-0.999 in the range 0.60-12 mol L-1. The limit of detection was 5.1 μmol kg-1, and the limit of quantification was 9.2 μmol kg-1. The recoveries varied from 84 to 97% with RSDs equal to or lower than 11%. The intra-day and inter-day repeatability values, expressed as the relative standard deviation, were less than 8.7 and 9.8, respectively. No obvious matrix effect existed in the different cosmetics matrices. The validated method was applied for the analysis of 57 commercial cosmetic samples. Graphical abstract Analysis of phthalates in cosmetics using a three-phase preparation method.
Keywords
article; chemical analysis; correlation; cosmetics; detection limit; ethanol; hydrolysates; hydrolysis; ingredients; phthalates; phthalic acid; pigments; solvents; tandem mass spectrometry
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Source - August 2018 Update
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