EFFECT OF PLATICIZERS ON IN VITRO RELEASE AND EX VIVO PERMEATION OF CHLORPHENIRAMINE MALEATE FROM ETHYL CELLULOSE POLYVINYL PYRROLIDONE BASED MATRIX PATCHES | Health & Environmental Research Online (HERO)

Health & Environmental Research Online (HERO)

Print Feedback Export to File

This record has one attached file:

Citation
Tags

HERO ID

4829041

Reference Type

Journal Article

Title

EFFECT OF PLATICIZERS ON IN VITRO RELEASE AND EX VIVO PERMEATION OF CHLORPHENIRAMINE MALEATE FROM ETHYL CELLULOSE POLYVINYL PYRROLIDONE BASED MATRIX PATCHES

Author(s)

Rajabalaya, R; David, SRN; Khanam, J; Nanda, A

Year

2013

Journal

Farmacia
ISSN: 0014-8237

Volume

Issue

Page Numbers

975-990

Web of Science Id

WOS:000325909700015

Abstract

The present release and permeation studies were carried out for developing transdermal therapeutic systems with chlorpheniramine maleate (CPM). The matrix patches were prepared from ethyl cellulose (EC) with polyvinyl pyrrolidone (PVP) as the copolymer and plasticizers like dibutyl phthalate (DBP), dibutyl sebacate (DBS), triethyl citrate (TEC), acetyl triethyl citrate (ATEC), tributyl citrate (TBC) and acetyl tributyl citrate (ATBC) in different percentages. Thickness, tensile strength, elasticity, drug content, moisture content and water absorption studies of the matrix patches were measured. In vitro release/permeation of CPM was studied in a modified Keshary - Chien diffusion cell. Experimental release/permeation data (percent release and flux, mu gm/cm(2).hr) of different formulations of the matrix systems are reported. Also the drug-polymer interaction was investigated by ATR-FTTR studies. This study reports the effect of CPM in EC patch and suitable amount of plasticizer for better controlled release/permeation of CPM; hence this drug could be a potential candidate for transdermal antihistamine applications in film device industry.

Keywords

Matrix patch; Chlorpheniramine malaeate; Ethyl cellulose; Polyvinyl pyrrolidone; Plasticizer