US EPA

4851281 

Journal Article 

Antimicrobial activity of Araucaria cunninghamii Sweet and the chemical constituents of its twigs and leaves 

Chen, J; Yang, ML; Zeng, J; Gao, K 

2013 

0 

Phytochemistry Letters
ISSN: 1874-3900
EISSN: 1876-7486 

6 

1 

41-45 

English 

10.1016/j.phytol.2012.10.013 

WOS:000314477900010 

The present study was aimed at the identification of antimicrobial components from Araucaria cunninghamii with an activity-guided purification process. Eight compounds were obtained from the most active n-BuOH fraction and identified as the new compound 4-n-butoxyl-phenylpropanetriol (1), together with seven known compounds (2a8). These compounds were tested for antimicrobial activities against five bacteria and four plant pathogenic fungi. Within the series of compounds tested, compound 2 was the most active, particularly displaying moderate antibacterial activities against Erwinia carotovora and Bacillus subtilis with MICs 7.8 and 15.5 mu g/ml. Moreover, this compound exhibited inhibitory activities against four plant pathogenic fungi: Helminthosporium sativum, Rhizoctonia solani, Fusarium oxysporum f. sp. Niveum and Fusarium oxysporum f. sp. Cubense, with EC50 values of 42.3, 90.0, 62.7 and 100.2 mu g/ml. To our knowledge, this is the first report that the n-BuOH fraction and compound 2 from A. cunninghamii showed inhibitory activity against plant pathogenic fungi.