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4923458 
Journal Article 
RIFM fragrance ingredient safety assessment, diethyl malonate, CAS Registry Number 105-53-3 
Api, AM; Belsito, D; Botelho, D; Bruze, M; Burton, GA; Buschmann, J; Dagli, ML; Date, M; Dekant, W; Deodhar, C; Francis, M; Fryer, AD; Jones, L; Joshi, K; La Cava, S; Lapczynski, A; Liebler, DC; O'Brien, D; Patel, A; Penning, TM; Ritacco, G; Romine, J; Sadekar, N; Salvito, D; Schultz, TW; Sipes, IG; Sullivan, G; Thakkar, Y; Tokura, Y; Tsang, S 
2018 
Yes 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
English 
Summary: The use of this material under current conditions is supported by existing information.

The material diethyl malonate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Target data show that diethyl malonate is not genotoxic. The repeated dose and reproductive toxicity endpoints were completed using dimethyl malonate (CAS# 108-59-8) as a read-across analog, which provided an MOE > 100. Data from target material and read-across analog, pentanedioic acid, 1,5-dimethyl ester (CAS# 1119-40-0) show that is material is not a concern for skin sensitization. The local respiratory toxicity endpoint was completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (1.4 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated; diethyl malonate was found not to be a PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are < 1. 
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