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Citation
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HERO ID
4923735
Reference Type
Journal Article
Title
[The effect of metabolites of the propionate pathway on the oxidative activity of liver mitochondria]
Author(s)
Fedotcheva, NI; Gessler, NN; BykhovskiÄ, VIa; Kondrashova, MN
Year
1991
Is Peer Reviewed?
1
Journal
Biokhimiya
ISSN:
0320-9725
Volume
56
Issue
3
Page Numbers
426-433
Language
Russian
PMID
1883904
Web of Science Id
BCI:BCI199192038804
Abstract
Methylmalonate and propionate, the major metabolites of the propionate pathway of fatty and amino acid metabolism used at 1-4 mM cause selective inhibition of succinate and palmitoyl carnitine oxidation in liver mitochondria. Methylmalonate is more specific towards succinate, whereas propionate--towards palmitoyl carnitine oxidation. Methylmalonate is transported to mitochondria at a high rate with no effect on succinate transport. Being injected intramusculary methylmalonate has no inhibiting effect on the oxidative activity of mitochondria but is able to activate succinate and palmitoyl carnitine oxidation. The inhibiting effect of propionate on palmitoyl carnitine oxidation is a long-term one. Injections of these metabolites precursors, isoleucine, methionine and valine, produce an activating effect on succinate oxidation. Thus, propionate pathway metabolites may participate in the regulation of lipid-carbohydrate metabolism.
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OPPT
•
Malonates
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