Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
4932656
Reference Type
Journal Article
Title
Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats
Author(s)
Bloedow, DC; Hayton, WL
Year
1976
Is Peer Reviewed?
Yes
Journal
Journal of Pharmaceutical Sciences
ISSN:
0022-3549
EISSN:
1520-6017
Volume
65
Issue
3
Page Numbers
328-334
Language
English
PMID
57233
Abstract
The effects of hexadecane, oleyl alcohol, polysorbate 80, trioctanoin, and triolein on the bioavailability of sulfisoxazole N1-acetyl, dicumarol, and griseofulvin were investigated. Compared to administration of the drugs in water, the rate of absorption of the drugs was either decreased or not changed by the lipids. The extent of absorption of sulfisoxazole acetyl and dicumarol was significantly increased by polysorbate 80 and triolein and not affected by hexadecane or oleyl alcohol. Tricotanoin increased the extent of abosrption of sulfisoxazole acetyl but had no effect on the absorption of dicumarol. Compared to the aqueous vehicle, the extent of absorption of greiseofulvin was decreased by hexadecane, oleyl alcohol, and triolein, increased by polysorbate 80, and not affected by trioctanoin. The extent of absorption of sulfisoxazole acetyl was not affected by the amount of triolein in which it was administered nor by emulsification of triolein prior to administration.
Tags
OPPT
•
Fatty Alcohols
Literature Search
Human Health
Toxline (private)
Environmental Hazard
Toxline (private)
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity