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HERO ID
4940253
Reference Type
Technical Report
Title
D-glucono-1,5-lactone: repeated dose toxicity: oral: 001 key | experimental result
Author(s)
European Chemicals Agency :: ECHA
Year
1978
Publisher
ECHA
Location
Helsinki, Finland
Number of Pages
8
Language
English
URL
https://echa.europa.eu/registration-dossier/-/registered-dossier/1952/7/6/2/?documentUUID=93daf682-ff67-4025-aacc-2ae69acd2f0b
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Abstract
The authors of this study reported that compound-related effects were observed in the stomach of rats and consisted of thickening of the stratified squamous epithelieum at the anterior stomach, which is perceived to pertain to the rat forestomach. The area particularly affected was the transitional area continuous with the pyloric stomach, which is consistent with a description of the limiting ridge. The effect was observed in all dose groups and was reported with dose dependency in frequency and severity, and therefore, a NOAEL for glucono delta lactone could not be determined based on the results of this study. However, given that the forestomach and limiting ridge are structures unique to the rodent, the effects observed in the stomach of rats in this study are not relevant to humans. It should be noted that the results reported herein were taken from a partial English translation of a study report written in Japanese.
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