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HERO ID
4946615
Reference Type
Journal Article
Title
Metabolism and disposition of dipropylene glycol monomethyl ether (DPGME) in male rats
Author(s)
Miller, RR; Hermann, EA; Calhoun, LL; Kastl, PE; Zakett, D
Year
1985
Is Peer Reviewed?
Yes
Journal
Fundamental and Applied Toxicology
ISSN:
0272-0590
EISSN:
1095-6832
Volume
5
Issue
4 (1985)
Page Numbers
721-726
Language
English
PMID
4043594
DOI
10.1016/0272-0590(85)90196-4
Web of Science Id
WOS:A1985ANR1200014
Abstract
Male Fischer 344 rats were given a single oral dose of approximately 1289 mg/kg (8.7 mmol/kg) of ( super(14)C)DPGME. After dosing, expired air, excreta, and tissues were analyzed for super(14)C activity, and metabolites in urine were isolated and identified. Approximately 60% of the administered super(14)C activity was excreted in urine, while 27% was eliminated as super(14)CO sub(2) within 48 hr after dosing. DPGME, PGME, dipropylene glycol, propylene glycol, as well as sulfate and glucuronide conjugates of DPGME were identified in urine of animals given ( super(14)C)DPGME. Results of the study indicate that DPGME is metabolized via the same routes to the same general types of metabolites as previously identified for propylene glycol monomethyl ether (PGME).
Keywords
disposition; metabolism
Tags
OPPT
•
Glycols
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