US EPA

4946771 

Journal Article 

Rational Design of Yolk-Shell CuO/Silicalite-1@mSiO2 Composites for a High-Performance Nonenzymatic Glucose Biosensor 

Cheng, X; Zhao, H; Huang, W; Chen, J; Wang, S; Dong, J; Deng, Y 

2018 

1 

Langmuir
ISSN: 0743-7463
EISSN: 1520-5827 

34 

26 

7663-7672 

English 

29871483 

10.1021/acs.langmuir.8b01051 

WOS:000438008200009 

In this study, an interface coassembly strategy is employed to rationally synthesize a yolk-shell CuO/silicalite-1@void@mSiO2 composite consisting of silicalite-1 supported CuO nanoparticles confined in the hollow space of mesoporous silica, and the obtained composite materials were used as a novel nonenzymatic biosensor for highly sensitive and selective detecting glucose with excellent anti-interference ability. The synthesis of CuO/silicalite-1@mSiO2 includes four steps: coating silicalite-1 particles with resorcinol-formaldehyde polymer (RF), immobilization of copper species, interface deposition of a mesoporous silica layer, and final calcination in air to decompose RF and form CuO nanoparticles. The unique hierarchical porous structure with mesopores and micropores is beneficial to selectively enrich glucose for fast oxidation into gluconic acid. Besides, the mesopores in the silica shell can effectively inhibit the large interfering substances or biomacromolecules diffusing into the void as well as the loss of CuO nanoparticles. The hollow chamber inside serves as a nanoreactor for glucose oxidation catalyzed by the active CuO nanoparticles, which are spatially accessible for glucose molecules. The nonenzymatic glucose biosensors based on CuO/silicalite-1@mSiO2 materials show excellent electrocatalytic sensing performance with a wide linear range (5-500 μM), high sensitivity (5.5 μA·mM-1·cm-2), low detection limit (0.17 μM), and high selectivity against interfering species. Furthermore, the unique sensors even display a good capability in the determination of glucose in real blood serum samples.