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HERO ID
4949228
Reference Type
Technical Report
Title
SIDS initial assessment report for SIAM 22. TOME 2: SIDS dossiers. Category name: long chain alcohols
Author(s)
Organisation for Economic Co-operation and Development :: OECD
Year
2006
Publisher
OECD
Location
Paris, France
Number of Pages
1644
Language
English
Abstract
SIDS dossiers already existed for 1-Dodecanol (CAS 112-53-8) and 1-Octadecanol (CAS 112-92-5) (published in 1998 and 1995 respectively); the present document updates and extends the earlier ones; brings in new information, and therefore replaces it. No conclusions drawn in the earlier review are amended.
Available data for these substances are compiled in SIDS dossiers related to each CAS number. The reliability of each data point has been considered during this period of review, in accordance with the guidance of the Fraunhofer Institut für Toxikologie und Aerosolforschung. The following standard reliability codes, defined by Klimisch et al. (1997)1, apply, in accordance with the SIDS guidance:
(1) Valid without restriction
(2) Valid with restrictions
(3) Invalid
(4) Not assignable.
Results considered to be Invalid are not used in the discussions or conclusions in this report. However, results which are of Non-assignable reliability may be fully valid, although insufficient details were available to be sure of this; therefore reliability (4) results are used in this report. The reliability code of each data point is given.
Key studies are flagged in the SIDS dossiers. These are studies with the highest reliability/adequacy. If several studies showed comparable reliability/ adequacy, the study with the lowest LC/LD/EC50 or NOEC/ NOAEL has been indicated as the key study. For some endpoints, fully reliable results are not available and it has been necessary to use a weight of evidence including results of studies of non-assignable reliability. In such cases the results are identified as key studies as they are of high importance to the data set.
For transparency, some study summaries in the SIDS dossier have been transferred from the previously published version of IUCLID or from the previous SIDS submission. In some cases, it has not been possible to retrieve the original literature/study reports using the reported citation or as a result of literature searching. In some cases, change of business ownership meant that internal study reports cited in previous summaries could not be accessed. In some other cases, e.g. certain non-SIDS endpoints, and in areas where a very large amount of literature has been published, it was not considered necessary to pursue all individual published sources due to weight of evidence of more reliable results. In all cases, reliability (4) applies, because the original documentation has not been reviewed in the development of the dossier. Such results are clearly identified in the SIDS dossier and more details are given therein.
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