The Health Hazard Evaluation Program received a request from the employer at an optical media production company who was concerned with the chemical odors generated during the production of compact discs and digital video discs. The company manufactured optical media using primarily resin, lacquer, ink, and screen wash chemicals. We evaluated employee exposures to volatile organic compounds (VOCs); spoke with managers and employees; observed workplace conditions, processes, and practices; and evaluated ventilation systems. We detected a variety of VOCs in short-term screening samples, but did not detect the target analytes of naphthalene, ethylbenzene, xylene, 2-butoxyethanol, or trimethylbenzene in any of the full-shift air samples. We observed a need for improved hazard communication (updating safety data sheets), training (consistent and proper use of personal protective equipment [PPE]), and availability of appropriate PPE. Although the smoke tests revealed that air moved from the hallways into the molding and printing departments, improvements could be made to local exhaust ventilation in the facility. In the last 6 months, the most commonly reported symptoms by employees were lightheadedness, headache, and dizziness and many employees reported a transient unpleasant odor or taste in their mouth. However, many employees reported their symptoms have recently subsided; some employees attributed the resolution of symptoms to improved ventilation. We recommended additional ventilation changes, improving hazard communication, and employees in the molding and printing departments wear nitrile gloves and long sleeves to prevent unnecessary dermal exposures to solvents.