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HERO ID
5043474
Reference Type
Journal Article
Title
In utero effects of maternal phthalate exposure on male genital development
Author(s)
Wineland, RJ; Bloom, MS; Cruze, L; Butts, CD; Wenzel, AG; Unal, ER; Kohno, S; Willan, KB; Brock, JW; Newman, RB
Year
2019
Is Peer Reviewed?
1
Journal
Prenatal Diagnosis
ISSN:
0197-3851
EISSN:
1097-0223
Volume
39
Issue
3
Page Numbers
209-218
Language
English
PMID
30476355
DOI
10.1002/pd.5398
Web of Science Id
WOS:000459798300009
Abstract
BACKGROUND:
Phthalates are used extensively in commercial and personal care products and maternal exposure is ubiquitous. Phthalates are anti-androgenic, but the potential effects of phthalates on male penile development have not been assessed in utero.
OBJECTIVE:
The study aims to investigate the association between early pregnancy phthalate exposure and fetal penile development, overall and by race.
METHODS:
Prospective cohort study of women with singleton pregnancies presenting for prenatal ultrasound between 18 and 22 weeks' gestation. Maternal urine samples were assayed for eight phthalate monoester metabolites. We used maternal phthalate levels at 18 to 22 weeks' gestation as predictors of fetal size using multiple linear regression models, adjusted for fetal gestational age, maternal age, race, smoking, and education. We incorporated a phthalate by race interaction into a second set of regression models.
RESULTS:
We detected statistically significant race interactions for continuous phthalates with penile width. Race interactions were also suggested for penile length and volume using tertiles of phthalates with point estimates generally positive for whites and negative for African Americans.
CONCLUSION:
Penile development is significantly influenced by race, and the impact of maternal phthalates on penile measurements also varies by race. Maternal phthalate exposure can adversely affect in utero penile growth and development, especially among African Americans.
Tags
IRIS
•
Phthalates – Targeted Search for Epidemiological Studies
Included
Source-March 2019 Update
WOS
Toxline
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