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5079965 
Journal Article 
Lycopene protects from perfluorooctanoic acid induced liver damage and uterine apoptosis in pregnant mice 
Song, P; Li, D; Wang, X; Zhong, X 
2019 
Yes 
International Journal of Clinical and Experimental Medicine
ISSN: 1940-5901 
12 
1 
212-219 
English 
WOS:000457202700021 
This study aimed to investigate the protective effects of lycopene on liver oxidative damage and decidual apoptosis induced by perfluorooctanoic acid (PFOA) in early pregnancy mice. Fifty pregnant mice were randomly divided into five groups of 10 each. Mice in the control group were fed with 0.1 mL of soybean oil every morning from gestation day (GD) 1-GD 7, while mice in the PFOA model group were fed with 20 mg/kg PFOA daily. Mice in the other three lycopene groups were fed with 20 mg/kg PFOA daily and different concentrations of lycopene at doses of 10 mg/kg (Low), 20 mg/kg (Medium), and 40 mg/kg (High). Liver and uterus samples were collected on GD 9 and the organ index was calculated. Contents of SOD, GSH-Px, and MDA in the liver homogenate were measured and expression of apoptotic proteins (Bax, Bcl-2, Fas, FasL, Caspase-3) in uterine cells was detected by immunohistochemistry. Weight loss in lycopene groups was alleviated, compared to the PFOA model group. Liver indexes decreased significantly in medium and high dose lycopene groups. Uterine indexes and average weights of medium and high groups were increased significantly (P<0.01). In addition, activities of SOD and GSH-Px were significantly elevated in the high dose group (E) and levels of MDA in medium- and high-dose lycopene groups were significantly lower than controls. Moreover, levels of Caspase-3 and Fas were significantly decreased in medium and high groups (P<0.01), while levels of Bcl-2 and FasL and Bcl-2/Bax ratios were significantly increased (P<0.01). Results of the present study revealed that lycopene ameliorated PFOA induced liver oxidative damage and uterine apoptosis in early pregnant mice. 
Lycopene; perfluorooctanoic acid; liver oxidative damage; uterine apoptosis; pregnant mice