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Citation
Tags
HERO ID
5080367
Reference Type
Journal Article
Subtype
Review
Title
Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies
Author(s)
Zeng, Z; Song, B; Xiao, R; Zeng, G; Gong, J; Chen, M; Xu, P; Zhang, P; Shen, M; Yi, H
Year
2019
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Volume
126
Page Numbers
598-610
Language
English
PMID
30856447
DOI
10.1016/j.envint.2019.03.002
Web of Science Id
WOS:000462597500068
Abstract
The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its human health risks over the past decade. In vivo and in vitro studies are important and effective means to ascertain the toxic effects of PFOS on humans and its toxic mechanisms. This article systematically reviews the human health risks of PFOS based on the currently known facts found by in vivo and in vitro studies from 2008 to 2018. Exposure to PFOS has caused hepatotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity, thyroid disruption, cardiovascular toxicity, pulmonary toxicity, and renal toxicity in laboratory animals and many in vitro human systems. These results and related epidemiological studies confirmed the human health risks of PFOS, especially for exposure via food and drinking water. Oxidative stress and physiological process disruption based on fatty acid similarity were widely studied mechanisms of PFOS toxicity. Future research for assessing the human health risks of PFOS is recommended in the chronic toxicity and molecular mechanisms, the application of various omics, and the integration of toxicological and epidemiological data.
Keywords
PFOS; Human health risk; In vivo; In vitro
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorinated compounds
Perfluorooctane
Perfluorooctanesulfonate
Perfluorooctanesulfonic acid
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
WOS
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