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Citation
Tags
HERO ID
5080379
Reference Type
Journal Article
Title
Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation
Author(s)
Ammitzbøll, C; Börnsen, L; Petersen, ER; Oturai, AB; Søndergaard, HB; Grandjean, P; Sellebjerg, F
Year
2019
Is Peer Reviewed?
Yes
Journal
Journal of Neuroimmunology
ISSN:
0165-5728
EISSN:
1872-8421
Publisher
Elsevier B.V.
Location
AMSTERDAM
Volume
330
Page Numbers
90-95
Language
English
PMID
30852181
DOI
10.1016/j.jneuroim.2019.03.002
Web of Science Id
WOS:000465057100018
URL
http://www.sciencedirect.com/science/article/pii/S0165572819300025
Exit
Abstract
Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.
Keywords
Alkanesulfonic Acids; Fluorocarbons; perfluorooctane sulfonic acid; 9H2MAI21CL; Index Medicus; Cross-Sectional Studies; Middle Aged; Risk Factors; Cohort Studies; Multiple Sclerosis -- diagnosis; Alkanesulfonic Acids -- blood; Multiple Sclerosis -- blood; Multiple Sclerosis -- immunology; Fluorocarbons -- toxicity; Alkanesulfonic Acids -- toxicity; Fluorocarbons -- blood; Alkanesulfonic Acids -- immunology; Immunity, Cellular -- drug effects; Immunity, Cellular -- immunology; Fluorocarbons -- immunology
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
TEDX
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Other Sources
PFAS TOX Database
Screened Studies
Excluded
Exclude (TIAB)
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
PFAS TOX Database
Not prioritized for screening
Perfluorooctane
Perfluorooctanesulfonic acid
•
PFDA
Scopus: April 2021
June 2022 Pelch Database
Submitted to EPA
•
PFHxS
Database searches
Scopus
Pelch PFAS SEM
Excluded
TiAb
Literature Search Update April 2023
Included Met PECO
•
PFNA
June 2022 Pelch Database
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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