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HERO ID
5080502
Reference Type
Journal Article
Title
Determination of 21 perfluoroalkyl substances and organophosphorus compounds in breast milk by liquid chromatography coupled to orbitrap high-resolution mass spectrometry
Author(s)
Beser, MI; Pardo, O; Beltrán, J; Yusà, V
Year
2019
Is Peer Reviewed?
Yes
Journal
Analytica Chimica Acta
ISSN:
0003-2670
EISSN:
1873-4324
Volume
1049
Page Numbers
123-132
Language
English
PMID
30612643
DOI
10.1016/j.aca.2018.10.033
Web of Science Id
WOS:000454789100014
Relationship(s)
is supplemented by
11368082
: Supplementary material
Abstract
The human exposure to perfluoroalkyl (PFASs) and organophosphorus (OPs) compounds is a cause of concern and its determination in biological matrices, including human milk, is an emergent approach for evaluate their exposure. A comprehensive strategy for the quantitative determination of 21 PFASs and OPs compounds in breast milk was developed. The proposed method includes an extraction and clean-up procedure based on the QuEChERs methodology followed by an ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) determination. The full-scan mass data were acquired with a resolution of 50000 FWHM and a mass accuracy better than 5 ppm. Method validation was performed in terms of recovery, repeatability, linearity and limit of quantification. The obtained recoveries varied between 70 and 120% with a precision (RSD) lower than 25%. The limit of quantification (LOQ) ranged between 1.9 and 19.0 ng g-1 lipid weight for OPs, and between 0.066 ng mL-1 and 0.666 ng mL-1 for PFASs. A breast milk reference material was used in order to check the validated method. The developed analytical strategy was applied to 20 breast milk samples collected from mothers living in the Valencian Region (Spain). All of the OPs analyzed except tris(2-chloroethyl) phosphate (TCEP) were detected in at least one sample. In all samples, perfluoro-n-pentanoic acid (PFPeA), perfluoro-n-octanoic acid (PFOA) and sodium perfluoro-1-octanesulfonate (PFOS) were the most frequently detected analytes. Concentration of total OPs (∑OPs) and total PFASs (∑PFASs) ranged from 1.9 to 37.7 ng g-1 lipid weight and from 0.066 to 0.356 ng mL-1, respectively.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Screened Studies
Supplemental
Perfluorinated compounds
Perfluorooctanesulfonic acid
Perfluorooctanoic acid
Perfluoropentanoic acid
Sodium perfluorooctanesulfonate
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
WOS
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