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HERO ID
5080517
Reference Type
Journal Article
Title
Cross-sectional study of the association between serum perfluorinated alkyl acid concentrations and dental caries among US adolescents (NHANES 1999-2012)
Author(s)
Puttige Ramesh, N; Arora, M; Braun, JM
Year
2019
Is Peer Reviewed?
1
Journal
BMJ Open
EISSN:
2044-6055
Publisher
BMJ PUBLISHING GROUP
Location
LONDON
Volume
9
Issue
2
Page Numbers
e024189
Language
English
PMID
30782897
DOI
10.1136/bmjopen-2018-024189
Web of Science Id
WOS:000471124600122
Abstract
STUDY OBJECTIVES:
Perfluoroalkyl acids (PFAAs) are a class of anthropogenic and persistent compounds that may impact some biological pathways related to oral health. The objective of our study was to estimate the relationship between dental caries prevalence and exposure to four PFAA: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS) in a nationally representative sample of US adolescents.
SETTING/DESIGN:
We analysed cross-sectional data from the National Health and Nutrition Examination Survey from 1999 to 2012 for 12-19-year-old US adolescents.
PARTICIPANTS:
Of 10 856 adolescents aged 12 to 19 years who had a dental examination, we included 2869 with laboratory measurements for serum PFAA concentrations and complete covariate data in our study.
PRIMARY AND SECONDARY OUTCOME MEASURES:
Dental caries prevalence was defined as the presence of decay or a restoration on any tooth surface, or the loss of a tooth due to tooth decay. We used multivariable logistic regression to estimate the covariate-adjusted association between serum PFAA concentrations and dental caries prevalence, accounting for the complex National Health and Nutrition Examination Survey design.
RESULTS:
Of 2869 adolescents, 59% had one or more dental caries. We observed no associations between the prevalence of dental caries and serum concentrations of PFOA, PFOS or PFHxS. The adjusted odds of caries were 21% (OR 0.79; 95% CI 0.63 to 1.01), 15% (OR 0.85; 95% CI 0.67 to 1.08) and 30% (OR 0.7; 95% CI 0.55 to 0.90) lower among adolescents in the 2nd, 3rd and 4th serum PFNA concentration quartiles compared to adolescents in the first quartile, respectively. The linear trend for this association was not statistically significant.
CONCLUSION:
PFOA, PFOS and PFHxS were not associated with prevalence of dental caries. The prevalence of caries was reduced with increasing serum PFNA concentrations; however, these results should be interpreted cautiously given that we were unable to adjust for several factors related to oral health.
Keywords
Index Medicus; 2019)
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
TEDX
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Other Sources
PFAS TOX Database
Screened Studies
Excluded
Exclude (TIAB)
Not prioritized for screening
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
PFAS TOX Database
Not prioritized for screening
Ammonium perfluorooctanoate
Perfluorohexanesulfonic acid
Perfluorononanoic acid
Perfluorooctane
Perfluorooctanesulfonic acid
Perfluorooctanoic acid
•
PFHxS
Database searches
Pubmed
WOS
Scopus
Pelch PFAS SEM
Inclusion
TiAb
Full Text
Human Study
•
PFNA
Literature Search
Pubmed
WOS
PFNA May 2019 Update
Pubmed
LitSearch: May 2019 - May 2020
WoS
Title and Abstract Screening
Full Text Screening
Studies Meeting PECO
Human health effects studies
June 2022 Pelch Database
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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