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Citation
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HERO ID
508139
Reference Type
Journal Article
Title
Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols
Author(s)
Padmanabhan, S; Melander, O; Hastie, C; Menni, C; Delles, C; Connell, JM; Dominiczak, AF
Year
2008
Is Peer Reviewed?
1
Journal
Journal of Hypertension
ISSN:
0263-6352
EISSN:
1473-5598
Volume
26
Issue
7
Page Numbers
1275-1281
Language
English
Abstract
Among the common complex diseases, hypertension has been particularly unlucky in the recent surge of positive results from genome-wide association studies. We summarize the evidence that would support continuing the effort in the hunt for a genetic basis for hypertension. The problems facing the genetic studies for hypertension are not unique, but phenotypic characterization, heterogeneity and high prevalence make it a special case requiring a more individualized approach. We argue that, even in the presence of a strong environmental component to hypertension risk, the common disease/common variant model is relevant for hypertension and discuss the issues involved in designing a genome-wide association study for hypertension. It is likely that the individual odds ratios for disease variants will be less than 1.3 and, although individually these effect sizes are minor, the combination of even a few such common polymorphisms can have substantial population attributable risks. The identification of hypertension gene variants should provide new insight into the disease susceptibility, progression and severity. This will lead to the identification of potential targets for lifestyle and pharmacological interventions, with the ultimate goal of improving prevention, diagnosis and treatment.
Keywords
genetics; genome-wide association; hypertension; polymorphism; pressure program fbpp; blood-pressure; environment interactions; population history; british genetics; common variant; susceptibility; family; loci; metaanalysis
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