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HERO ID
5094676
Reference Type
Journal Article
Title
Structure and Function of an Inflammatory Cytokine, Interleukin-2, Analyzed Using the Bioinformatic Approach
Author(s)
Roy, U
Year
2019
Is Peer Reviewed?
1
Journal
Protein Journal
ISSN:
1573-4943
EISSN:
15734943
Language
English
PMID
31006082
DOI
10.1007/s10930-019-09833-8
Abstract
The inflammatory cytokine, interleukin-2 (IL-2), is an important regulator of cellular functions. This relatively less studied member of the interleukin protein family is responsible for multiple immuno-modulatory and immuno-stimulatory tasks, like T cell activation, triggering of natural killer cells, inflammation, as well as proliferation and progression of autoimmune diseases and cancers. In this communication we report the temporally variant structural aspects of the IL-2 ligand and its receptor interfaces, based on the available crystal structures. The intended goal of this effort is to generate simulated results that could potentially aid the designs of novel structure based therapeutics.
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