Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
5101359
Reference Type
Journal Article
Subtype
Review
Title
Multiple low-level exposures: Hg interactions with co-occurring neurotoxic substances in early life
Author(s)
Dórea, JG
Year
2019
Is Peer Reviewed?
1
Journal
Biochimica et Biophysica Acta. General Subjects
ISSN:
0304-4165
EISSN:
1872-8006
Publisher
ELSEVIER
Location
AMSTERDAM
Volume
1863
Issue
12
Page Numbers
29243-29243
Language
English
PMID
30385391
DOI
10.1016/j.bbagen.2018.10.015
Web of Science Id
WOS:000495476600008
URL
http:///www.elsevier.com
Exit
Abstract
All chemical forms of Hg can affect neurodevelopment; however, low levels of organic Hg (methylmercury-MeHg and ethylmercury-EtHg in Thimerosal-containing vaccines, hereafter 'TCV') exposures during early life (pregnancy and lactation) co-occur with other environmental neurotoxic substances. These neurotoxicants may act in parallel, synergistically, or antagonistically to Hg. Nevertheless, the risks of neurotoxicity associated with multiple neuro-toxicants depend on type, time, combinations of exposure, and environmental and/or genetic-associated factors. Neurological developmental disorders, delays in cognition and behavioral outcomes associated with multiple exposures (which include Hg) may show transient or lasting outcomes depending on constitutional and/or environmental factors that can interact to neutralize, aggravate or attenuate these effects; often these studies are challenging to interpret. During pregnancy and lactation, fish-MeHg exposure is frequently confounded with the opposing effects of neuroactive nutrients (in fish) that lead to positive, negative, or no effects on neurobehavioral tests. In infancy, exposures to acute binary mixtures (TCV- EtHg and Al-adjuvants in infant immunizations) are associated with increased risks of tics and other developmental disorders. Despite the certitude that promulgates single environmental neurotoxicants, empirical comparisons of combined exposures indicate that Hg-related outcome is uneven. Hg in combination with other neurotoxic mixtures may elevate risks of neurotoxicity, but these risks arise in circumstances that are not yet predictable. Therefore, to achieve the goals of the Minamata treaty and to safeguard the health of children, low levels of mercury exposure (in any chemical form) needs to be further reduced whether the source is environmental (air- and food-borne) or iatrogenic (pediatric TCVs).
Keywords
Biophysics; Biochemistry & Molecular Biology; Mercury, Neurodevelopment, Pregnancy, Infants, Children, Breastfeeding; thimerosal-containing vaccines, autism spectrum disorders, organic; mercury-compounds, umbilical-cord blood, attention deficit/hyperactivity; disorder, potential health consequences, hepatitis-b vaccination,; skin-lightening creams, breast-fed infants, inuit children
Tags
IRIS
•
Methylmercury
Literature Search: Mar 2017 - May 2019
Food Studies
Human Data
PubMed
Scopus
ToxNet
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity