Synthesis of (S) and (R)-tilisolol hydrochloride
Qian, S; Ye, XJ; Zheng, F; Yang, L; Wu, Y
| HERO ID | 5175181 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Synthesis of (S) and (R)-tilisolol hydrochloride |
| Authors | Qian, S; Ye, XJ; Zheng, F; Yang, L; Wu, Y |
| Journal | Chinese Chemical Letters |
| Volume | 20 |
| Issue | 6 |
| Page Numbers | 648-650 |
| Abstract | Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, 1a and 1b were synthesized from inexpensive phthalic anhydride 2 in eight steps with 13% (S) and 15% (R) overall yield. |
| Doi | 10.1016/j.cclet.2008.12.048 |
| Wosid | WOS:000267094600005 |
| Url | http://www.sciencedirect.com/science/article/pii/S1001841708005895 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Tilisolol hydrochloride; Optical; Synthesis |