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5175181 
Journal Article 
Synthesis of (S) and (R)-tilisolol hydrochloride 
Qian, S; Ye, XJ; Zheng, F; Yang, L; Wu, Y 
2009 
1 
Chinese Chemical Letters
ISSN: 1001-8417
EISSN: 1878-5964 
ELSEVIER SCIENCE INC 
NEW YORK 
20 
6 
648-650 
WOS:000267094600005 
Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, 1a and 1b were synthesized from inexpensive phthalic anhydride 2 in eight steps with 13% (S) and 15% (R) overall yield. 
Tilisolol hydrochloride; Optical; Synthesis