A convenient method for the preparation of 4-hydroxy-2-methyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid derivatives
Blanco, MM; Shmidt, MS; Schapira, CB; Perillo, IA
| HERO ID | 5175477 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | A convenient method for the preparation of 4-hydroxy-2-methyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid derivatives |
| Authors | Blanco, MM; Shmidt, MS; Schapira, CB; Perillo, IA |
| Journal | Synthesis |
| Issue | 12 |
| Page Numbers | 1971-1974 |
| Abstract | An improved method for the synthesis of 4-hydroxy-2methyl-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid derivatives is described. The synthetic route involves initial phthalic anhydride aminolysis with alkylaminoacetic acid derivatives. further esterification with diazomethane and final heterocyclization of the phthalamic ester intermediates by alkoxide-induced Dieckmann condensation. The best yields are reached for esters and N,N-disubstituted carboxamides. |
| Doi | 10.1055/s-2006-942402 |
| Wosid | WOS:000238841100011 |
| Url | <Go to ISI>://CCC:000238841100011http://www.thieme.de |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: SYNTHESIS-STUTTGART ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Chemistry; Polymer Science; heterocycles, isoquinolinones, cyclization, lactams, enols; isocyano compounds |