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HERO ID
5185441
Reference Type
Journal Article
Title
Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice
Author(s)
Singh, S; Singh, SK
Year
2019
Is Peer Reviewed?
Yes
Journal
Journal of Applied Toxicology
ISSN:
0260-437X
EISSN:
1099-1263
Volume
39
Issue
3
Page Numbers
420-431
Language
English
PMID
30294798
DOI
10.1002/jat.3733
Web of Science Id
WOS:000459208900002
URL
https://search.proquest.com/docview/2183987265?accountid=171501
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Abstract
Perfluoroalkyl acids (PFAAs) are widely used in commercial applications and that they are ubiquitous and persistent in the environment. Perfluorononanoic acid (PFNA), a member of PFAAs, has been detected in human and wildlife. Previous acute exposure studies have shown the adverse effect of PFNA on the testis. The present study was aimed to examine the effect of chronic PFNA exposure, from prepuberty to adulthood, on testicular functions and fertility in Parkes (P) male mice and to investigate the possible mechanism(s) of its action. PFNA (0.2 and 0.5 mg/kg) was orally administered to P male mice for 90 days from prepuberty (postnatal day [PND] 25) to adulthood (PND 114). Histologically, testes in PFNA-treated mice showed non-uniform degenerative changes in the seminiferous tubules. The treatment also had adverse effects on testicular expression of steroidogenic markers, serum levels of cholesterol and testosterone, sperm parameters and on litter size. A marked increase in the level of lipid peroxidation and decrease in the activities of antioxidant enzymes were observed in the testis of PFNA-treated mice compared to controls. Further, a significant decrease in expression of proliferating cell nuclear antigen (PCNA) and in the number of PCNA-positive cells, and an increase in expression of caspase-3 were also noted in PFNA-treated mice testis. In conclusion, the results suggest that chronic exposure to PFNA in male mice interferes with testosterone biosynthesis and causes oxidative stress in the testis, leading to alterations in spermatogenesis, sperm quality and fertility potential.
Keywords
Environmental Studies--Toxicology And Environmental Safety; fertility; oxidative stress; perfluorononanoic acid; spermatogenesis; steroidogenesis; Side effects; Testosterone; Cholesterol; Oral administration; Lipid peroxidation; Exposure; Perfluoro compounds; Rodents; Proliferating cell nuclear antigen; Antioxidants; Peroxidation; Perfluoroalkyls; Serum levels; Biosynthesis; Wildlife; Tubules; Chronic exposure; Caspase
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
TEDX
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Other Sources
PFAS TOX Database
Screened Studies
Excluded
Exclude (TIAB)
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
PFAS TOX Database
Not prioritized for screening
Perfluorinated compounds
Perfluorononanoic acid
•
PFHxS
•
PFNA
Literature Search
WOS
PFNA May 2019 Update
Web of Science
LitSearch: May 2019 - May 2020
WoS
Background/Exposure References
Title and Abstract Screening
Full Text Screening
Studies Meeting PECO
Animal health effects studies
June 2022 Pelch Database
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