1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide
Sathitkarnmanee, T; Tribuddharat, S; Nonlhaopol, D; Thananun, M; Somdee, W
| HERO ID | 5395741 |
|---|---|
| In Press | No |
| Year | 2015 |
| Title | 1-1-12 one-step wash-in scheme for desflurane low flow anesthesia: performance without nitrous oxide |
| Authors | Sathitkarnmanee, T; Tribuddharat, S; Nonlhaopol, D; Thananun, M; Somdee, W |
| Journal | Drug Design, Development and Therapy |
| Volume | 9 |
| Page Numbers | 977-981 |
| Abstract | <strong>BACKGROUND: </strong>We reported a 1-1-12 wash-in scheme for desflurane-nitrous oxide (N2O) low flow anesthesia that is simple, rapid, and predictable. There remain some situations where N2O should be avoided, which limits the generalizability of this wash-in scheme. The objective of our study was to determine the performance of this scheme in contexts where N2O is not used.<br /><br /><strong>METHODS: </strong>We recruited 106 patients scheduled for elective surgery under general anesthesia. After induction and intubation, wash-in was started with a fresh gas flow of air:O2 1:1 L/min and a vaporizer concentration of desflurane of 12%. Controlled ventilation was then adjusted to maintain PACO2 at 30-35 mmHg.<br /><br /><strong>RESULTS: </strong>The alveolar concentration of desflurane (FAD) rose rapidly from 0% to 6% in 4 minutes in the same pattern as observed in our previous study in which N2O was used. An FAD of 7% was achieved in 6 minutes. An FAD of 1% to 7% occurred at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. The rise in heart rate during wash-in was statistically significant, although not clinically so. There was a slight but statistically significant decrease in blood pressure, but this had no clinical significance.<br /><br /><strong>CONCLUSION: </strong>Performance of the 1-1-12 wash-in scheme is independent of the use of N2O. Respective FADs of 1%, 2%, 3%, 4%, 5%, 6%, and 7% can be expected at 0.6, 1, 1.5, 2, 3, 4, and 6 minutes. |
| Doi | 10.2147/DDDT.S78233 |
| Pmid | 25733815 |
| Wosid | WOS:000349529300003 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |