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HERO ID
5488911
Reference Type
Journal Article
Title
Phthalate exposure and cumulative risk in a Chinese newborn population
Author(s)
Li, X; Liu, L; Wang, H; Zhang, X; Xiao, T; Shen, H
Year
2019
Is Peer Reviewed?
Yes
Journal
Environmental Science and Pollution Research
ISSN:
0944-1344
EISSN:
1614-7499
Publisher
Springer Verlag
Location
Heidelberg
Volume
26
Issue
8
Page Numbers
7763-7771
Language
English
PMID
30673950
DOI
10.1007/s11356-019-04216-z
Web of Science Id
WOS:000463824600040
URL
https://search.proquest.com/docview/2237526252?accountid=171501
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Abstract
Phthalates have been attracted as a considerable attention in toxicological research as well as public health context due to their ubiquitous occurrence and potential adverse health effects. Newborns are susceptible to the environmental risk factors; however, data are still limited on newborn phthalate exposure and risk assessment worldwide, especially in China. This study was nested in a cross-sectional retrospective study of 1359 pregnant women recruited in Xiamen Maternity and Child Care Hospital, China, during June to July 2012. All urine samples from newborn were collected using disposal diapers during the first two postnatal days, and seven phthalate metabolites were measured by LC-ESI-MS/MS. Phthalate exposure and accumulation risk were evaluated based on the measured newborn urinary internal doses. The detection rate (96.5%) and the median concentration (17.5 ng/mL) of mono-n-butyl phthalate (MBP) were the highest, while monobenzyl phthalate (MBzP) concentration was the lowest with a detection rate (1.50%). By estimating the daily intakes of the parent phthalates, their EDI were 0.04, 0.10, 0.32, 0.00, and 0.12 μg/kg-bw/day for dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalates (DBP), benzyl butyl phthalate (BBzP), and di-(2-ethylhexyl) phthalate (DEHP), respectively. The newborns were commonly exposed to phthalates but no one exceeds the regulated tolerable daily intake (TDI) values in this large newborn population.
Keywords
Newborn; Phthalate exposure; Urinary metabolite concentrations; Risk assessment; Daily intake; Tolerable daily intake
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IRIS
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Diethyl phthalate (DEP)
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