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HERO ID
5620298
Reference Type
Journal Article
Title
Personal care products use and phthalate exposure levels among pregnant women
Author(s)
Hsieh, CJ; Chang, YH; Hu, A; Chen, ML; Sun, CW; Situmorang, RF; Wu, MT; Wang, SL; TMICS study group
Year
2019
Is Peer Reviewed?
1
Journal
Science of the Total Environment
ISSN:
0048-9697
EISSN:
1879-1026
Publisher
Elsevier B.V.
Volume
648
Page Numbers
135-143
Language
English
PMID
30114584
DOI
10.1016/j.scitotenv.2018.08.149
Web of Science Id
WOS:000447805500014
URL
https://search.proquest.com/docview/2153615214?accountid=171501
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Abstract
Fetuses are susceptible to phthalates, known endocrine disrupting chemicals, within sensitive windows of development. It is crucial to determine the major sources of phthalates to reduce exposure. This study aims to examine the associations between usage patterns of personal care products (PCPs) and urinary levels of phthalate metabolites across pregnancy in a multi-hospital based birth cohort.During 2012–2015, we conducted a birth cohort study named the Taiwan Mother Infant Cohort Study (TMICS). Usage patterns of PCPs were obtained using structured questionnaires during the third trimester of pregnancy. Spot urine samples were collected at each trimester, and levels of eleven phthalate metabolites were measured by liquid chromatography tandem mass spectrometry. The association of PCPs use with urinary phthalate metabolite concentrations was assessed using GEE models.Among the 1676 pregnant women participated in TMICS, 281 who provided two or three urine samples across pregnancy were included. The levels of several phthalate metabolites were significantly associated with the use of PCPs, particularly leave-on PCPs. With the increasing use of skin toners (11.7%; 95% CI: 1.5%, 22.9%), lipsticks (13.2%; 95% CI: 4.6%, 22.5%), and essential oils (21.8%; 95% CI: 9.1%, 36.0%), individuals are exposed to higher concentrations of mono-ethyl phthalate (MEP). Additionally, a positive trend was found regarding the number of leave-on PCPs used and the measured change in MEP concentrations (P for trend = 0.01). Other positive associations included MBzP and body lotions (7.9%; 95% CI: 0.1%, 16.2%). With regard to rinse-off PCPs, we found a positive association between urinary MBzP and shampoo use, and a negative association between urinary MMP and face wash.Leave-on PCPs were found to be a more probable source of phthalate exposure than the use of rinse-off PCPs. We suggest pregnant women reduce the frequency of leave-on PCPs use during pregnancy to avoid such phthalate exposure.
Keywords
article; Phthalate; Pregnancy; Personal care product; Repeated measurement; cohort studies; cosmetics; endocrine-disrupting chemicals; essential oils; liquid chromatography; metabolites; phthalates; pregnant women; questionnaires; tandem mass spectrometry
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch July 2017 - Sept 2018
New from Previous
Pubmed
•
Diethyl phthalate (DEP)
Database searches
Jan 2020 update
PubMed
Web of Science
New for this project
Excluded: No Primary Data on Health Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Excluded
Source-March 2019 Update
WOS
Toxline
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