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Citation
Tags
HERO ID
5882885
Reference Type
Journal Article
Title
Zwitterionic Hydrogels Based on a Degradable Disulfide Carboxybetaine Cross-Linker
Author(s)
Jain, P; Hung, HC; Li, B; Ma, J; Dong, D; Lin, X; Sinclair, A; Zhang, P; O'Kelly, MB; Niu, L; Jiang, S
Year
2019
Is Peer Reviewed?
1
Journal
Langmuir
ISSN:
0743-7463
EISSN:
1520-5827
Volume
35
Issue
5
Page Numbers
1864-1871
Language
English
PMID
30119608
DOI
10.1021/acs.langmuir.8b02100
Abstract
We report the synthesis of a zwitterionic carboxybetaine disulfide cross-linker (CBX-SS) and biodegradable poly(carboxybetaine) (PCB) hydrogels and nanocages (NCs) made using this cross-linker. The structure of CBX-SS combines zwitterionic carboxybetaine to confer nonfouling properties and a disulfide linkage to facilitate degradation. The physical, mechanical, and fouling characteristics of PCB hydrogels cross-linked with CBX-SS were investigated. Then, the degradation characteristics of CBX-SS-cross-linked hydrogels were evaluated through their weight loss and release of an encapsulated protein in a reducing environment. Furthermore, CBX-SS was applied to prepare degradable PCB NCs. Results show that encapsulating the highly immunogenic enzyme uricase in degradable PCB NCs eliminates or prevents an in vivo immune response to both the protein and polymer.
Tags
IRIS
•
PCBs
Excluded
Litsearches
Litsearch: Aug 2017 - Aug 2018
PubMed
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