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Citation
Tags
HERO ID
5935661
Reference Type
Journal Article
Subtype
Review
Title
Mechanisms of environmental contributions to fatty liver disease
Author(s)
Wahlang, B; Jin, J; Beier, JI; Hardesty, JE; Daly, EF; Schnegelberger, RD; Falkner, KC; Prough, RA; Kirpich, IA; Cave, MC
Year
2019
Is Peer Reviewed?
1
Journal
Current Environmental Health Reports
EISSN:
2196-5412
Volume
6
Issue
3
Page Numbers
80-94
Language
English
PMID
31134516
DOI
10.1007/s40572-019-00232-w
Web of Science Id
WOS:000544903000002
URL
http://
://WOS:000544903000002
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Abstract
PURPOSE:
Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and environmental chemical exposures is termed "toxicant-associated steatohepatitis" (TASH). The current review addresses the scientific progress made in the mechanistic understanding of TASH since its initial description in 2010.
RECENT FINDINGS:
Recently discovered modes of actions for volatile organic compounds and persistent organic pollutants include the following: (i) the endocrine-, metabolism-, and signaling-disrupting chemical hypotheses; (ii) chemical-nutrient interactions and the "two-hit" hypothesis. These key hypotheses were then reviewed in the context of the steatosis adverse outcome pathway (AOP) proposed by the US Environmental Protection Agency. The conceptual understanding of the contribution of environmental exposures to FLD has progressed significantly. However, because this is a new research area, more studies including mechanistic human data are required to address current knowledge gaps.
Tags
•
PCBs
Supplemental
Litsearches
Litsearch: Aug 2019 - Aug 2020
PubMed
PFAS
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch Update: November 2021
Web of Science
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
Web of Science
Perfluorooctane
•
PFHxS
Background References
•
PFNA
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (Apr 2019 - Sep 2020)
WOS
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