Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
595430
Reference Type
Journal Article
Title
Genotoxic studies of vanadium pentoxide (V2O5) in male mice. II. Effects in several mouse tissues
Author(s)
Altamirano-Lozano, M; Valverde, M; Alvarez-Barrera, L; Molina, B; Rojas, E
Year
1999
Is Peer Reviewed?
1
Journal
Teratogenesis, Carcinogenesis, and Mutagenesis
ISSN:
0270-3211
EISSN:
1520-6866
Volume
19
Issue
4
Page Numbers
243-255
Language
English
PMID
10406888
DOI
10.1002/(SICI)1520-6866(1999)19:4<243::AID-TCM1>3.0.CO;2-J
Web of Science Id
WOS:000081466500001
Abstract
Vanadium pentoxide (V2O5) was tested for its ability to induce genotoxic damage in six different organs (liver, kidney, lung, spleen, heart, and bone marrow) of mice by using the alkaline Single Cell Gel Electrophoresis (SCGE) assay. Animals were sacrificed 24 h after i.p. administration of the vanadium pentoxide of 23.0, 11.5, or 5.75 microg/g (corresponding to the LD50, 1/2 LD50 and 1/4 LD50, respectively). In all tissues and organs evaluated (except for bone marrow), V2O5 increased the number of cells with damage. Our results showed that i.p. injection of V2O5 induced DNA damage in different organs and tissues, and that this kind of damage can be observed even 24 h after treatment. The analysis of DNA migration and the distribution of DNA damage showed that there are differences in sensitivity between organs and tissues to this compound. In addition the sensitivity of SCGE assay allows the detection of long term DNA damage and the possibility to compare it in various tissues and target organs.
Keywords
vanadium pentoxide; V2O5; single cell gel electrophoresis assay;
tissues of mice; genotoxicity
Tags
IRIS
•
Vanadium Compounds - Problem Formulation
Manual review of existing IRIS and PPRTV assessments
IRIS 2011/2014
PPRTV 2008
Combined data set
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Mechanistic
Non-oral route of administration
From IARC 2006
From PPRTV 2008&2009
•
Vanadium Inhalation
Combined Dataset
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Mechanistic (genotoxic)
Non-inhalation route
Manual review of existing IRIS and PPRTV assessments
From IARC 2006
From PPRTV 2008 & 2009
•
Vanadium Pentoxide (Draft, 2011)
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity