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6311630 
Journal Article 
Exposure to Perfluoroalkyl Substances in a Cohort of Women Firefighters and Office Workers in San Francisco 
Trowbridge, J; Gerona, RR; Lin, T; Rudel, RA; Bessonneau, V; Buren, H; Morello-Frosch, R 
2020 
Yes 
Environmental Science and Technology
ISSN: 0013-936X
EISSN: 1520-5851 
54 
3363-3374 
English 
Studies of firefighters have shown increased exposures to carcinogenic compounds and elevated rates of certain cancers compared to the general population, yet this research has focused almost exclusively on men. To address this gap, the Women Firefighters Biomonitoring Collaborative created a biological sample archive and analyzed levels of perfluoroalkyl substances (PFAS) among women firefighters (N = 86) and office workers (N = 84) in San Francisco. Serum samples were collected and analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) to measure and compare PFAS levels between firefighters and office workers. 7 of 12 PFAS congeners were detected in the least 70% of the study population, and 4 congeners were detected in 100% of participants. In regression models comparing PFAS levels by occupation and adjusting for potential confounders, firefighters had higher geometric mean concentrations of PFAS compared to office workers PFHxS (2.22 (95% CI = 1.55, 3.18)), PFUnDA (1.83 (95% CI = 0.97, 3.45)), and PFNA (1.26 (95% CI = 1.01, 1.58)). Among firefighters, occupational position predicted exposure-firefighters and officers had higher PFNA, PFOA, PFDA, and PFUnDA levels compared to drivers. Women firefighters are exposed to higher levels of some PFAS compared to office workers, suggesting that some of these exposures may be occupationally related. 
Environmental Studies; Mass spectrometry; Firefighters; Liquid chromatography; Biomonitoring; Perfluoroalkyls; Carcinogens; Occupational exposure; Regression analysis; Regression models; Exposure; Mass spectroscopy; Population studies; Firefighter services; Congeners; San Francisco California 
• PFDA
     Literature Search Update 5/2020
          PubMed
• PFHxS
     LitSearch: May 2019 - May 2020
          PubMed
• PFNA
     LitSearch: May 2019 - May 2020
          PubMed
          WoS
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          WoS
          PubMed