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6311645 
Journal Article 
Intrauterine exposure to perfluorinated compounds and overweight at age 4: A case-control study 
Martinsson, M; Nielsen, C; Björk, J; Rylander, L; Malmqvist, E; Lindh, C; Rignell-Hydbom, A 
2020 
Yes 
PLoS ONE
EISSN: 1932-6203 
15 
e0230137 
English 
AIMS: The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight.

METHODS: We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m2) and 2 controls per case (ISO-BMI ≤17 kg/m2) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in biobanked samples collected by routine around gestational week 14. Logistic regression was used to estimate odds ratios between quartiles of maternal serum levels and child overweight at age 4.

RESULTS: There were no consistent monotonic exposure-response relationships. We found some significant odds ratios in specific quartiles but these were regarded as spurious findings. The absence of an effect was consistent over risk strata.

CONCLUSIONS: We did not find evidence of an association between maternal serum levels of PFOS, PFOA, PFHxS and PFNA in early pregnancy and child overweight at age 4. The level of other risk factors for overweight did not affect children's susceptibility to prenatal PFAS exposure. 
Sciences: Comprehensive Works; Pregnancy; Children; Medical risk factors; Child health; Childhood obesity; Birth weight; Body mass index; Intrauterine exposure; Childrens health; Population; Level (quantity); Risk factors; Questionnaires; Dose-response effects; Families & family life; Environmental health; Exposure; Perfluoro compounds; Risk analysis; Body weight; Quartiles; Medicine; Heterogeneity; Perfluorooctanoic acid; Serum levels; Studies; Obesity; Regression analysis; Sulfonates; Children & youth; Quality control; Perfluorohexane; Soft drinks; Prenatal experience 
• PFHxS
     LitSearch: May 2019 - May 2020
          PubMed
• PFNA
     LitSearch: May 2019 - May 2020
          PubMed
• PFOA (335-67-1) and PFOS (1763-23-1)
     LitSearch: Feb 2019 - May 2020
          PubMed
     Literature Search Update (Apr 2019 - Sep 2020)
          PubMed
          WOS