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HERO ID
6324501
Reference Type
Journal Article
Title
Exposure of adult mice to perfluorobutanesulfonate impacts ovarian functions through hypothyroxinemia leading to down-regulation of Akt-mTOR signaling
Author(s)
Cao, XY; Liu, J; Zhang, YJ; Wang, Y; Xiong, JW; Wu, J; Chen, L
Year
2020
Is Peer Reviewed?
Yes
Journal
Chemosphere
ISSN:
0045-6535
EISSN:
1879-1298
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
244
Page Numbers
125497
Language
English
PMID
31809938
DOI
10.1016/j.chemosphere.2019.125497
Web of Science Id
WOS:000515197700045
Abstract
Perfluorobutanesulfonate (PFBS), a short-chain perfluoroalkyl substance, is used in many industrial products. Preliminary evidence suggests that exposure to PFBS may increase the risk of infertility. The aim of this study was to investigate the influence of PFBS on ovarian function. Herein, we show that exposure of adult female mice to PFBS (200 mg/kg/day) (PFBS-mice) caused a decrease in the levels of serum total triiodothyronine and thyroxine, which depended on the activation of peroxisome proliferator-activated receptor α (PPARα). The numbers of secondary, early antral and antral follicles were reduced in PFBS-mice with an increase in the atretic follicles, and these changes were recovered by the replacement of L-thyroxinein or the treatment with PPARα antagonist GW6471. PFBS-induced hypothyroxinemia led to a decrease in the levels of Akt, mTOR and p70S6K phosphorylation in ovarian granular cells and cumulus cells, which suppressed the proliferation of these cells and enhanced autophagic death of granular cells and cumulus cells. The levels of serum estradiol and progesterone were reduced in PFBS-mice with a low expression of the steroidogenic genes Star and P450scc in ovarian tissues, which were sensitive to the replacement of L-thyroxinein or the blockade of PPARα. The results indicate that exposure to PFBS (≥200 mg/kg/day) through reducing thyroid hormones causes down-regulation of Akt-mTOR signaling in granular cells and cumulus cells, leading to the deficits in the development of follicles and the biosynthesis of ovarian hormones.
Keywords
Perfluorobutanesulfonate (PFBS); Hypothyroxinemia; Mechanistic target of rapamycin (mTOR); Folliculogenesis; Steroidogenesis
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch Update: November 2021
Web of Science
Perfluorooctane
•
PFAS 150
Literature Search Update December 2021
PubMed
WOS
Missing 2021 searches
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Perfluorinated compounds
Perfluorobutanesulfonate
Perfluorobutanesulfonyl fluoride
Perfluorooctane
•
PFBS
Search
PubMed
WOS
Lit Search Update: May 2019 - May 2020
WoS
PubMed
Scopus: April 2021
•
PFHxS
•
PFOA (335-67-1) and PFOS (1763-23-1)
LitSearch: Feb 2019 - May 2020
WoS
Literature Search Update (Apr 2019 - Sep 2020)
WOS
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