US EPA

64601 

Journal Article 

Effects of mononitroparaffins and related compounds on blood pressure and respiration of rabbits 

Machle, W; Scott, EW 

1943 

1 

Proceedings of the Society for Experimental Biology and Medicine
ISSN: 0037-9727
EISSN: 1525-1373 

NIOSH/00061522 

53 

42-43 

The toxicity of the following mononitroparaffins was tested in experimental studies: nitromethane (75525); nitroethane (79243); 1-nitropropane (108032); 2-nitropropane (79469); 1-nitrobutane (627054); 2-nitrobutane (600248); 2-nitro-2-methyl-propanol (124685); 2-nitro-2-methyl-,3-propanediol; tris-(hydroxymethyl)nitromethane; 2-amino-2-methyl-1-propanol; 2-amino-2-methyl-1,3-propanediol (115695); tris-(hydroxymethyl)methylamine (the last 3 were tested as hydrochlorides). The first 6 compounds showed no significant effect on blood pressure or respiration of rabbits. A graph is given of the effects of nitroethane and 2-nitropropane on rabbit blood pressure as compared with effects induced by glycerol-trinitrate, erythrityl-tetranitrate (7297258) and sodium-nitrite (7632000). The nitrates and sodium-nitrite had greater effect in smaller doses than did the nitroparaffins. 

DCN-174202; Patty; Methanes; Amines; Propanols; Propanes; Butanes; Ethanes; Paraffins