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Citation
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HERO ID
65024
Reference Type
Journal Article
Title
Teratology studies on orally administered chloroform in the rat and rabbit
Author(s)
Thompson, DJ; Warner, SD; Robinson, VB
Year
1974
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Volume
29
Issue
3
Page Numbers
348-357
Language
English
PMID
4283698
DOI
10.1016/0041-008X(74)90107-0
Web of Science Id
WOS:A1974U014400003
URL
http://dx.doi.org/10.1016/0041-008X(74)90107-0
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Abstract
The effect of orally administered chloroform on embryonal and fetal development was evaluated in the rat and rabbit. Doses of 0, 20, 50, or 126 mg/kg/day in the rat, and 0, 20, 35, or 50 mg/kg/day in the rabbit were given on days 6–15 and 6–18 of gestation, respectively. Fetuses were removed by cesarean section 1 or 2 days prior to expected parturition and were examined for external, skeletal, and/or soft tissue abnormalities. The occurrence of anorexia and weight gain suppression in dams of both species, as well as subclinical nephrosis in the rat and hepatotoxicity in the rabbit, indicated that maximum tolerated doses of chloroform were used. Fetotoxicity in the form of reduced birth weights was observed at the highest dose level in both species. There was no evidence of teratogenicity in either species at any dose tested.
Tags
•
Chloroform 2018 Update
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Identified from other sources
Excluded Studies
Excluded, but considered supplemental information
•
Chloroform Combined (current)
Chloroform (original)
Chloroform (2018 update)
TITLE AND ABSTRACT REVIEW
January 2009 Literature Search
Identified from other sources
Excluded Studies
Excluded, but considered supplemental information
Chloroform (current)
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