Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature
Hollingworth, M; Sims-Williams, HP; Pickering, AE; Barua, N; Patel, NK
| HERO ID | 6546939 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2017 |
| Title | Single Electrode Deep Brain Stimulation with Dual Targeting at Dual Frequency for the Treatment of Chronic Pain: A Case Series and Review of the Literature |
| Authors | Hollingworth, M; Sims-Williams, HP; Pickering, AE; Barua, N; Patel, NK |
| Journal | Brain Sciences |
| Volume | 7 |
| Issue | 1 |
| Abstract | Deep Brain Stimulation (DBS) has been used to target many deep brain structures for the treatment of chronic pain. The periaqueductal grey and periventricular grey (PAG/PVG) is an effective target but results are variable, sometimes short-lived or subject to tolerance. The centromedian intra-laminar parafascicular complex (CMPf) modulates medial pain pathways and CMPf DBS may address the affective aspects of pain perception. Stimulation of multiple deep brain targets may offer a strategy to optimize management of patients with complex pain symptomatology. However, previous attempts to stimulate multiple targets requires multiple trajectories and considerable expense. Using a single electrode to stimulate multiple targets would help overcome these challenges. A pre-requisite of such a technique is the ability to use different stimulation parameters at different contacts simultaneously on the same electrode. We describe a novel technique in 3 patients with chronic pain syndromes for whom conventional medical and/or neuromodulation therapy had failed using a single electrode technique to stimulate PVG/PAG and CMPf at dual frequencies. |
| Doi | 10.3390/brainsci7010009 |
| Pmid | 28098766 |
| Wosid | WOS:000395483700008 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |