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HERO ID
1299282
Reference Type
Journal Article
Title
Vanadium induced ultrastructural changes and apoptosis in male germ cells
Author(s)
Aragón, MA; Ayala, ME; Fortoul, TI; Bizarro, P; Altamirano-Lozano, M
Year
2005
Is Peer Reviewed?
1
Journal
Reproductive Toxicology
ISSN:
0890-6238
EISSN:
1873-1708
Volume
20
Issue
1
Page Numbers
127-134
Language
English
PMID
15808796
DOI
10.1016/j.reprotox.2004.11.016
Abstract
Vanadium is a transition metal that is emitted to the atmosphere during combustion of fossil fuels. In the environment, vanadium occurs in the (V) oxidized form, but in the body it is found exclusively in the (IV) oxidized form. Vanadium tetraoxide is an inorganic chemical species in the (IV) oxidized form that has been shown to induce toxic effects in vitro and in vivo. The reproductive toxicity of vanadium in males was studied through monitoring germ cell apoptosis during spermatogenesis. We analyzed ultrastructural damage, and testosterone and progesterone concentrations following vanadium tetraoxide administered to male mice for 60 days. Spermatogenesis stages I-III and X-XII frequently showed apoptotic germ cells in control and treated animals; vanadium tetraoxide treatment induced an increase in the number of germ cell apoptosis in stages I-III and XII at 9.4 and 18.8 mg/kg, respectively. Although spermatogenesis is regulated by testosterone, in our study this hormone level was not modified by vanadium administration; thus, germ cell death was not related with testosterone concentration. At the ultrastructural level, we observed inclusion structures that varied as to location and content in the Sertoli and germ cells.
Keywords
Air Pollutants/*toxicity; Animals; Apoptosis/*drug effects; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred Strains; Progesterone/blood; Seminiferous Epithelium/*drug effects/ultrastructure; Spermatogenesis/*drug effects; Testosterone/blood; Vanadium/*toxicity; 0 (Air Pollutants); 57-83-0 (Progesterone); 58-22-0 (Testosterone); 7440-62-2 (Vanadium)
Tags
IRIS
•
Vanadium Compounds - Problem Formulation
Manual review of existing IRIS and PPRTV assessments
IRIS 2011/2014
Combined data set
Dataset for title/abstract screening
Dataset for full text screening
Supplemental (full text)
Supplemental material
Mechanistic
Non-oral route of administration
From 2011 V2O5 IRIS assessment
•
Vanadium Inhalation
Combined Dataset
Dataset for title/abstract screening
Supplemental (TIAB)
Supplemental material
Mechanistic (nongenotoxic)
Manual review of existing IRIS and PPRTV assessments
From 2011/2014 V2O5 IRIS assessment
•
Vanadium Pentoxide (Draft, 2011)
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