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HERO ID
669
Reference Type
Journal Article
Title
Long-term ambient concentrations of particulates and oxidants and development of chronic disease in a cohort of nonsmoking California residents
Author(s)
Abbey, DE; Lebowitz, MD; Mills, PK; Petersen, FF; Beeson, WL; Burchette, RJ
Year
1995
Is Peer Reviewed?
Yes
Journal
Inhalation Toxicology
ISSN:
0895-8378
EISSN:
1091-7691
Volume
7
Issue
1
Page Numbers
19-34
DOI
10.3109/08958379509014268
Web of Science Id
WOS:A1995QC60600004
Abstract
California Air Resources Board. A cohort of 6340 nonsmoking California Seventh-Day Adventists (SDAs) who had resided within 5 miles of their present residence for the past 10 yr has been followed since 1977 for incidence of cancer and myocardial infarction (MI) through 1982; development of definite symptoms of, and increasing severity of, airway obstructive disease (AOD), chronic bronchitis, and asthma through 1987; and all natural cause mortality through 1987. Cumulative ambient concentrations of specific pollutants have been estimated for study participants from 1967 to 1987 by interpolating monthly statistics from statewide air monitoring stations to ZIP codes of residence and work location. Statistics include excess concentrations and exceedance frequencies above a number of cutoffs as well as mean ambient concentration and mean ambient concentration adjusted for time spent indoors. Indoor sources or nitrogen (NO2), and of particulate pollution such as environmental tobacco smoke, both at home and at work, as well as occupational dusts and fumes, have been adjusted for in multivariate statistical models. Particulates included total suspended particulates (TSP), monitored from 1973 to 1987; inhalable particulates less than 10"mu"m in diameter (PM-10), estimated from site/seasonal-specific regressions on TSP for 1973-1987; fine particulates less than 2.5 "mu"m in diameter estimated from airport visibility data for 1967-1987; and suspended sulfates (SO4), monitored from 1977 to 1987. A direct measure of visibility, and gaseous pollutants-ozone, sulfur dioxide (SO2), and (NO2)-monitored from 1973 to 1987 were also included in analyses. No statistically significant associations between any of the disease outcomes studied and NO2 or SO2 were found in this cohort. None of the pollutants studied showed statistically significant associations with all natural cause mortality or incidence of all malignant neoplasms in males. Statistically significant associations were observed between elevated ambient concentrations of one or more particulate pollutants and each of the other disease outcomes. In addition, ozone was significantly associated with increasing severity of asthma, and with the development of asthma in males. Multi pollutant analyses indicated that none of the associations between particulate pollutants and disease outcomes were due to correlations with gaseous pollutants studied except possibly for PM2.5 and increasing severity of asthma, which could be due to a correlation with ozone. Observed associations between disease outcomes and PM2.5 or PM-10 could be biased toward the null because of increased measurement error due to their indirect methods of estimation.
Conference Name
In: Phalen, R. F.; Bates, D. V., eds. Proceedings of the colloquium on particulate air pollution and human mortality and morbidity; January 1994; Irvine, CA. Inhalation Toxicol. 7: 19-34.
Conference Location
Irvine, CA
Tags
NAAQS
•
ISA-NOx (2016)
Considered
Health Effects
•
ISA-PM (2009 Final Project Page)
2009 Final
•
MSA-Multipollutant Exposure Metric Review
Original Lit Search April 2013
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