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6903098 
Journal Article 
Synthesis of 2-(4-substitutedsulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one 
Acharyulu, PVR; Dubey, PK; Reddy, PVVP; Suresh, T; , 
2010 
1 
Indian Journal of Chemistry. Section B
ISSN: 0376-4699
EISSN: 0975-0983 
NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR 
NEW DELHI 
923-928 
WOS:000280343400002 
Reaction of 2-(chloromethyl)-3-arylquinazolin-4(3H)-one 3 with N-BOC piperzine 4 in acetonitrile using K2CO3 and KI, followed by deprotection BOC group in IPA HCl, gives 3-aryl-2-(piperazin-1-yl)quinazolin-4(3H)-one 6. The latter on treatment with benzene/methane sulfonyl chloride in DCM in the presence of TEA at RT, results in the formation of 2-(4-benzene/methane sulfonylpiperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one 7. Alternatively, 7 can also he prepared from the reaction of 4-benzene/methane sulfonyl-piperazine 9 with 3, in the presence of K2CO3 and KI.