Synthesis of 2-(4-substitutedsulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one
Acharyulu, PVR; Dubey, PK; Reddy, PVVP; Suresh, T; ,
| HERO ID | 6903098 |
|---|---|
| In Press | No |
| Year | 2010 |
| Title | Synthesis of 2-(4-substitutedsulfonyl piperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one |
| Authors | Acharyulu, PVR; Dubey, PK; Reddy, PVVP; Suresh, T; , |
| Journal | Indian Journal of Chemistry. Section B |
| Page Numbers | 923-928 |
| Abstract | Reaction of 2-(chloromethyl)-3-arylquinazolin-4(3H)-one 3 with N-BOC piperzine 4 in acetonitrile using K2CO3 and KI, followed by deprotection BOC group in IPA HCl, gives 3-aryl-2-(piperazin-1-yl)quinazolin-4(3H)-one 6. The latter on treatment with benzene/methane sulfonyl chloride in DCM in the presence of TEA at RT, results in the formation of 2-(4-benzene/methane sulfonylpiperazin-1-yl-methyl)-3-aryl-quinazolin-4(3H)-one 7. Alternatively, 7 can also he prepared from the reaction of 4-benzene/methane sulfonyl-piperazine 9 with 3, in the presence of K2CO3 and KI. |
| Wosid | WOS:000280343400002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |