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Citation
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HERO ID
698503
Reference Type
Journal Article
Title
Toxicology of a series of phthalate esters
Author(s)
Calley, D; Autian, J; Guess, WL
Year
1966
Is Peer Reviewed?
Yes
Journal
Journal of Pharmaceutical Sciences
ISSN:
0022-3549
EISSN:
1520-6017
Publisher
Elsevier
Volume
55
Issue
2
Page Numbers
158-162
Language
English
PMID
5923262
DOI
10.1002/jps.2600550206
URL
https://onlinelibrary.wiley.com/doi/abs/10.1002/jps.2600550206
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Abstract
Certain types of plastic materials require the addition of appreciable quantities of plasticizers to impart specific physical-chemical properties to the final item. Presently, many vinyl devices used with drug products may contain plasticizers of the phthalate type. For this reason, a series of phthalic acid esters were evaluated for parenteral toxicity including LD50 values and hexobarbital narcosis. Experiments utilized in the study also included i.p. injections in mice for acute toxicity profiles, i.v. administration in rabbits for blood pressure and respiration effects, and intradermal injections into rabbits for irritation effects. A further study was conducted to note what effects repeated i.p. doses of the phthalates would have on mice over a period of time, examining the effects on organs, weight gain, and the blood. Finally, tissue culture experiments were conducted to attempt to correlate certain of the toxicity manifestations. The most salient feature of the toxicity of these compounds was the central depression on the animals and the rather low order of toxicity by the parenteral route of administration.
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Additional Search Strategies
Studies with Health Effects Data
Animal toxicology studies
•
Dibutyl Phthalate (DBP)
Studies with Supporting Data
Mechanistic and genotoxicity studies
•
Diethyl phthalate (DEP)
Additional Strategies
Primary source of health effects
Animal toxicology studies
Excluded from hazard evaluation
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