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6996694 
Journal Article 
The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of canine osteoarthritis 
Vijarnsorn, M; Kwananocha, I; Kashemsant, N; Jarudecha, T; Lekcharoensuk, C; Beale, B; Peirone, B; Lascelles, BDX 
2019 
Yes 
BMC Veterinary Research
ISSN: 1746-6148 
15 
1 
English 
31623621 
WOS:000490969600002 
NSAIDs are accepted as the most predictably efficacious medical treatment of the clinical signs of osteoarthritis (OA). The marine-based fatty-acid compound PCSO-524 has been proposed as an adjunctive treatment for canine OA, however benefits of this agent is still controversial. The purpose of this study was to evaluate and compare the effectiveness of PCSO-524 combined with the NSAID firocoxib using force plate gait analysis, orthopedic assessment score (OAS) and canine brief pain inventory score (CBPI) in dogs with OA. A prospective, randomized, double-blinded study was conducted. Seventy-nine dogs that had hip and/or stifle OA were assigned randomly into three treatment groups: firocoxib, PCSO-524 and combination of firocoxib and PCSO-524, orally for 4 weeks. Peak vertical force (PVF, expressed as a percentage of bodyweight), OAS, CBPI, serum prostaglandin E2 concentration, hematology and blood chemistry values were evaluated before treatment (Day0), as well as at the second (Day14) and fourth week (Day28) during treatment. 
Osteoarthritis; Treatment; PCSO-524; NSAIDs; Firocoxib; Gait analysis; Dog