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HERO ID
699820
Reference Type
Journal Article
Title
KI-67 AND hTERT expression can aid in the distinction between malignant and benign pheochromocytoma and paraganglioma
Author(s)
Elder, E; Xu, D; Höög, A; Enberg, U; Hou, M; Pisa, P; Gruber, A; Larsson, C; Bäckdahl, M
Year
2003
Is Peer Reviewed?
1
Journal
Modern Pathology
ISSN:
0893-3952
EISSN:
1530-0285
Volume
16
Issue
3
Page Numbers
246-255
Language
English
PMID
12640105
DOI
10.1097/01.MP.0000056982.07160.E3
Abstract
The clinical and histopathological distinction between benign and malignant pheochromocytomas and paragangliomas is difficult, and reliable diagnostic markers are lacking. Here we have evaluated the prognostic value of human telomerase reverse transcriptase (hTERT) gene expression detected by reverse transcription PCR (RT-PCR); telomerase activity (TA) measured by TRAP (telomeric repeat amplification protocol) assay; immunohistochemical staining for Ki-67/MIB-1; and the mRNA expression of matrix metalloproteinase (MMP)-2 and EMMPRIN (extracellular matrix metalloproteinase inducer) analyzed by in situ hybridization in 32 primary pheochromocytomas or abdominal paragangliomas. hTERT was expressed in 7/11 malignant tumors (defined as presence of metastasis and/or extensive local invasion) as compared with in 2/21 benign tumors. All of the benign tumors showed <1% proliferative activity, as measured by Ki-67/MIB-1 staining. In all three patients with malignant tumors who developed metastases and/or invasive local recurrence during follow-up, the tumors were positive for either hTERT expression or Ki-67/MIB-1 immunoreactivity. TA was not a significant discriminator between benign and malignant tumors, and the value of EMMPRIN and MMP-2 as predictive markers was limited. In conclusion, the findings imply that the combined use of Ki-67/MIB-1 and hTERT, in addition to histopathology, provides a highly specific tool to identify benign pheochromocytoma and abdominal paraganglioma cases that are not at risk of developing recurrent or metastatic disease.
Tag
IRIS
•
Hexachloroethane (HCE) (Final, 2011)
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