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7059619 
Journal Article 
The Rab GTPase family 
Stenmark, H; Olkkonen, VM; , 
2001 
Yes 
Genome Biology
ISSN: 1474-7596
EISSN: 1474-760X 
BMC 
LONDON 
English 
11387043 
WOS:000207584000004 
The Rab family is part of the Ras superfamily of small GTPases. There are at least 60 Rab genes in the human genome, and a number of Rab GTPases are conserved from yeast to humans. The different Rab GTPases are localized to the cytosolic face of specific intracellular membranes, where they function as regulators of distinct steps in membrane traffic pathways. In the GTP-bound form, the Rab GTPases recruit specific sets of effector proteins onto membranes. Through their effectors, Rab GTPases regulate vesicle formation, actin- and tubulin-dependent vesicle movement, and membrane fusion.