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Citation
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HERO ID
709487
Reference Type
Journal Article
Subtype
Review
Title
A review of carcinogenicity studies of asbestos and non-asbestos tremolite and other amphiboles
Author(s)
Addison, J; Mcconnell, E
Year
2008
Is Peer Reviewed?
1
Journal
Regulatory Toxicology and Pharmacology
ISSN:
0273-2300
EISSN:
1096-0295
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Location
SAN DIEGO
Volume
52
Issue
1 Suppl
Page Numbers
S187-S199
Language
English
PMID
18006199
DOI
10.1016/j.yrtph.2007.10.001
Web of Science Id
WOS:000261438200021
URL
http://linkinghub.elsevier.com/retrieve/pii/S0273230007001493
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Abstract
Experimental animal studies comparing asbestos and non-asbestos varieties of tremolite indicate tremolite asbestos is markedly more carcinogenic. By direct analogy, the differences in carcinogenicity between tremolite asbestos and non-asbestos prismatic tremolite should be the same for the other types of amphibole that also crystallize in the asbestos and non-asbestos habits. The earliest of the experiment animal studies, done more than 25 years ago, have design limitations by modern standards including the use of injection or surgical implantation as the route of administration rather than the more relevant route of inhalation. However, the differences in the carcinogenicity of amphibole asbestos and non-asbestos amphiboles are sufficiently large to be clearly discernable even with the study limitations. Together with later studies on these and related minerals, there is strong evidence of a much lower hazard associated with the shorter, thicker fibers of the non-asbestos amphiboles, than is found for the asbestos analogues of the same mineral. It is possible that the non-asbestos amphiboles are no more hazardous than other silicate minerals widely considered nuisance dusts.
Keywords
Amphibole; Asbestos; Tremolite; Carcinogenic
Conference Name
International Symposium on Health Hazzard Evaluation of Fibrous Particles Associated with Taconite and Adjacent Duluth Complex
Conference Location
St Paul, MI
Tags
IRIS
•
Asbestos
•
Trimethylbenzenes (TMB)
NAAQS
•
ISA-Lead (2013 Final Project Page)
Considered
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Secondary source/ Review
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
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