Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

7183415

Reference Type

Journal Article

Title

Protection against liver injury by PGE1 or anti-TNF-alpha is associated with a reduction of TNF-R1 expression in hepatocytes

Author(s)

Lozano, JM; Collado, JA; Medina, T; Muntané, J; ,

Year

2003

Is Peer Reviewed?

Journal

Scandinavian Journal of Gastroenterology
ISSN: 0036-5521
EISSN: 1502-7708

Publisher

TAYLOR & FRANCIS AS

Location

OSLO

Page Numbers

1169-1175

Language

English

PMID

14686721

DOI

10.1080/00365520310006063

Web of Science Id

WOS:000186927400010

Abstract

Tumour necrosis factor-alpha (TNF-5) has been shown to exacerbate or protect against liver injury in different experimental models. In a previous study, we observed that enhancement of TNF-alpha expression in hepatocytes by prostaglandin E1 (PGE1) pre-administration induced iNOS expression and cytoprotection against experimental liver injury in rats. Nevertheless, the reduction of TNF-alpha bioactivity by anti-TNF-alpha antibodies also reduced liver injury by D-GalN. The purpose of the present study was to evaluate whether protection by PGE1 or anti-TNF-alpha was related to a common effect on the membrane-bound TNF-alpha receptor expression.