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HERO ID
730079
Reference Type
Journal Article
Title
Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells
Author(s)
Zhou, H; Randers-Pehrson, G; Geard, CR; Brenner, DJ; Hall, EJ; Hei, TK
Year
2003
Is Peer Reviewed?
1
Journal
Radiation Research
ISSN:
0033-7587
EISSN:
1954-2002
Volume
160
Issue
5
Page Numbers
512-516
Language
English
PMID
14565832
Abstract
Two conflicting phenomena, the bystander effect and the adaptive response, are important in determining biological responses at low doses of radiation and have the potential to have an impact on the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we reported previously that nonirradiated cells acquired mutagenesis through direct contact with cells whose nuclei had previously been traversed with either a single or 20 alpha particles each. Here we show that pretreatment of cells with a low dose of X rays 4 h before alpha-particle irradiation significantly decreased this bystander mutagenic response. Furthermore, bystander cells showed an increase in sensitivity after a subsequent challenging dose of X rays. Results from the present study address some of the pressing issues regarding both the actual target size and the radiation dose response and can improve on our current understanding of radiation risk assessment.
Tags
IRIS
•
Trichloroethylene (TCE) (Final, 2011)
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Hazard
Cancer Epi
Liver Issues
OPPT REs
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
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•
OPPT_Trichloroethylene (TCE)_D. Exposure
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OPPT_Trichloroethylene (TCE)_E. Fate
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OPPT_Trichloroethylene (TCE)_F. Human Health
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