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Citation
Tags
HERO ID
730120
Reference Type
Journal Article
Title
Trichloroethylene and trichloroacetic acid regulate calcium signaling pathways in murine embryonal carcinoma cells p19
Author(s)
Selmin, OI; Thorne, PA; Caldwell, PT; Taylor, MR
Year
2008
Is Peer Reviewed?
Yes
Journal
Cardiovascular Toxicology
ISSN:
1530-7905
EISSN:
1559-0259
Volume
8
Issue
2
Page Numbers
47-56
Language
English
PMID
18437584
DOI
10.1007/s12012-008-9014-2
Web of Science Id
WOS:000257368300001
Abstract
Trichloroethylene (TCE) and its metabolite trichloroacetic acid (TCA) are ubiquitous environmental contaminants which have been regarded as risk factors for congenital heart malformations. An increasing body of evidence from in vivo and in vitro studies supports the notion that exposure to TCE and TCA may interfere with normal embryonic heart development. The expression of several genes coding for factors implicated in the regulation of cardiac development has been shown to be modified by TCE or TCA, but the molecular mechanisms that mediate these effects are still obscure. In this study, we investigated the global changes in gene expression caused by exposure of P19 embryonal carcinoma cells to TCE and TCA, and whether or not TCE and/or TCA influence the expression levels of genes encoding for proteins that regulate calcium fluxes in cardiac cells. We report that TCE and TCA disrupt the expression of genes involved in processes important during embryonic development suggesting that exposure to environmentally significant concentrations of TCE may have deleterious effects on specific stages of cardiac differentiation.
Tags
•
Trichloroacetic acid (TCA) (Final, 2011)
•
Trichloroethylene (TCE) (Final, 2011)
All References
Hazard
Repro/Dev
OPPT REs
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Cited in IRIS document or IRIS HERO page
On topic - additional tags for titles/abstracts
MOA
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