Health & Environmental Research Online (HERO)


Print Feedback Export to File
7366573 
Journal Article 
Review 
A ticking clock links metabolic pathways and organ systems function in health and disease 
Vinciguerra, M; Tevy, MF; Mazzoccoli, G 
2014 
Yes 
Clinical and Experimental Medicine
ISSN: 1591-8890
EISSN: 1591-9528 
14 
2 
133-140 
English 
23553127 
WOS:000335152900003 
Rhythmic variations with 24-h periodicity hallmark homeostatic regulation, metabolic processes and organ systems function, driven by a circadian timing system composed of central and peripheral oscillators. Recent reports suggest that disrupted circadian rhythmicity of physiology and behavior severely alters body homeostasis. Nuclear receptors and transcriptional regulators sense hormonal and metabolic cues and manage the rhythmic patterns of chromatin remodelling and gene expression, playing a key role in the cross talk between the circadian clock circuitry, the metabolic pathways and the organ systems. The alteration of this cross talk contributes to the pathophysiology of metabolic, degenerative, immune-related and neoplastic diseases.